Mathematical Modeling of Water-Soluble Astaxanthin Release from Binary Polysaccharide/Gelatin Blend Matrices

Water-soluble AstaSana astaxanthin (AST) was loaded into 75/25 blend films made of polysaccharides (carboxymethyl cellulose (CMC), gum Arabic (GAR), starch sodium octenyl succinate (OSA), water-soluble soy (WSSP)) and gelatin (GEL) at levels 0.25, 0.5, 1%, respectively. Due to the presence granules in AST formulation, supplemented exhibited increased surface roughness as compared AST-free films. Apart from CMC/GEL carrier, migration water (25 °C, 32 h) incomplete. Excluding CMC-based gradual rise concentration decreased release rate. The Hopfenberg with time lag model provided best fit for all series data. Based on quarter-release times (t25%), 0.25% AST-supplemented OSA/GEL film (t25% = 13.34 ensured a 1.9, 2.2, 148.2 slower GAR-, WSSP- carriers, According Korsmeyer–Peppas model, offered quasi-Fickian (n < 0.5) burst effect (t100% 0.5–1 h). In general, other multi-mechanistic > 0.5), i.e., controlled least by Fickian diffusion polymer relaxation (erosion) mechanism. 1% AST-added WSSP/GEL system most linear profile.